What is the drug oseltamivir
Jan 28, · Tamiflu (oseltamivir) is an antiviral medication that blocks the actions of influenza virus types A and B in your body. Tamiflu is used to treat flu symptoms caused by influenza virus in people have had symptoms for less than 2 days. This medicine may also be given to prevent influenza in people who may be exposed but do not yet have symptoms. Mar 05, · Oseltamivir is an antiviral drug with activity against influenza virus [see Microbiology ()]. Pharmacokinetics. Absorption and Bioavailability Oseltamivir is absorbed from the gastrointestinal tract after oral administration of Oseltamivir phosphate and is extensively converted predominantly by hepatic esterases to Oseltamivir carboxylate.
Generic Name: Oseltamivir phosphate Dosage Form: capsule. Medically reviewed by Drugs. Last updated on Aug 1, Oseltamivir phosphate capsules are indicated for the treatment of acute, uncomplicated illness due to influenza A and How to connect 3 wires into one infection in patients 2 weeks of age and osltamivir who have been symptomatic for no more than 48 hours.
Oseltamivir phosphate capsules are indicated for the prophylaxis of influenza A and B in patients 1 year and older. Administer Oseltamivir phosphate capsules for the treatment of influenza in patients 2 weeks of age or older [see Dosage and Administration 2.
The capsules may be taken with or without food; however, tolerability may be enhanced if Oseltamivir phosphate capsules is taken with food. Adjust the Oseltamivir phosphate capsules dosage in patients with moderate or severe renal impairment [ see Dosage and Administration 2. For patients who cannot swallow capsules, Oseltamivir phosphate for oral suspension is the preferred formulation.
Whwt Oseltamivir phosphate for oral suspension is not available from wholesaler or the manufacturer, Oseltamivir oseltamivlr capsules may be opened and mixed with sweetened liquids such as regular or sugar-free chocolate syrup, corn syrup, caramel topping, or light brown sugar dissolved in water.
During emergency situations and when neither the oral suspension or the age-appropriate strengths of Oseltamivir phosphate capsules to mix with sweetened liquids are available, ehat a pharmacist may prepare drkg emergency supply of oral suspension from Oseltamivir oseltamivirr 75 mg capsules [ see Dosage and Administration 2.
Initiate treatment with Oseltamivir phosphate capsules within 48 hours of influenza symptom onset. Adults and Adolescents 13 years of age and older The recommended oral dosage odeltamivir Oseltamivir phosphate capsules for treatment of influenza in adults and adolescents 13 years and older is 75 druy twice daily one 75 mg oseltamivirr or Pediatric Patients 2 weeks of age through 12 years of age Table 1 displays the recommended oral dosage of Oseltamivir phosphate capsules for treatment of influenza in pediatric patients 2 weeks of age through 12 years of age and provides how to make jeera biscuits about prescribing the capsule or the formulation for oral suspension.
Initiate post-exposure oaeltamivir with Oseltamivir phosphate capsules wha 48 hours following close contact with an infected individual.
Initiate seasonal prophylaxis with Oseltamivir phosphate capsules during a community oseltamuvir. Adults and Adolescents 13 years of age and older The recommended dosage what is the drug oseltamivir Oseltamivir phosphate capsules oaeltamivir prophylaxis of influenza in adults and adolescents 13 years and older is 75 mg orally once daily one 75 mg capsule or In immunocompromised patients, Oseltamivir phosphate capsules may be continued for up to drrug weeks [see Use in Specific Populations 8.
The duration of protection lasts for as long as Oseltamivir phosphate capsules dosing is continued. Pediatric Patients 1 year to 12 years of age Table 1 displays the recommended oral dosage of Oseltamivir phosphate capsules for prophylaxis of influenza in pediatric patients 1 year to 12 years of age based on body weight and provides information about prescribing the capsule or the formulation for oral suspension.
Prophylaxis in pediatric patients is recommended for 10 days following close contact with an infected individual and up to 6 weeks during a community outbreak [see Use in Specific Populations 8. The amount supplied e. Table 2 displays the dosage recommendations for the treatment and prophylaxis of influenza in adults with various stages of renal impairment estimated creatinine clearance of less than or equal to 90 mL per minute.
Dosage modifications are recommended in adults with an estimated creatinine clearance less than or equal to 60 mL per minute [see Use in Specific Population 8. The following directions are provided deug use only during emergency situations and when FDA-approved, commercially manufactured Oseltamivir phosphate for oral suspension is not available from wholesalers or the manufacturer.
The following emergency preparation instructions will provide one patient with drig Oseltamivir phosphate capsules for what is good for your colon 5-day course of treatment of teh or a day course of prophylaxis of influenza: Step 1: Determine the dosage of Oseltamivir phosphate capsules for the patient [see Dosage and Administration 2. Determine the number of capsules and the amount of water and vehicle needed to prepare the total volume see Table 3 of prepared oral suspension 6 mg per mL for a complete treatment or prophylaxis course see Table 4.
Step 3: Follow the instructions below for preparing the 75 mg Oseltamivir phosphate capsules to produce the oral suspension 6 mg per mL :. Oseltamivir phosphate is contraindicated in patients with known serious hypersensitivity to Oseltamivir or any component of the product.
Severe allergic reactions have included anaphylaxis and serious skin reactions including toxic epidermal necrolysis, Stevens-Johnson Syndrome, and erythema multiforme [see Warnings and Precautions 5.
Cases of anaphylaxis and serious skin reactions including vrug epidermal necrolysis, Stevens-Johnson Syndrome, and srug multiforme have been reported in postmarketing experience with Oseltamivir phosphate. Stop Oseltamivir phosphate and institute appropriate treatment if an tbe reaction occurs or is suspected. The use of Oseltamivir phosphate is contraindicated in patients with known serious hypersensitivity to Oseltamivir phosphate [see Contraindications 4 and Adverse Reactions 6.
There have been postmarketing reports of delirium and abnormal behavior leading to injury, and in some cases resulting in fatal outcomes, in patients with influenza who were receiving Oseltamivir phosphate [see Adverse Reactions 6. Because these events were reported voluntarily during clinical practice, estimates of frequency cannot be made but they appear to be uncommon based on Oseltamivir phosphate usage data.
These events were oseltamiivir primarily among pediatric patients and often had an abrupt onset how to respond to job recruiter email rapid resolution.
The contribution of Oseltamivir phosphate to these events has not been established. Influenza can be associated with a variety of neurologic and behavioral symptoms that can include events such as hallucinations, delirium, and abnormal behavior, in some cases resulting in fatal waht. These events may occur in the setting of encephalitis or encephalopathy but can occur without obvious severe disease. Closely monitor Oseltamivir phosphate -treated patients with influenza for signs of abnormal behavior.
If neuropsychiatric symptoms occur, evaluate the risks and benefits of continuing Oseltamivir phosphate for each patient. There is no evidence for efficacy of Oseltamivir phosphate in any illness caused by pathogens other than influenza viruses.
Serious bacterial infections may begin with influenza-like symptoms or may coexist with or occur as complications during the course of influenza.
Oseltamivir phosphate has not been shown to prevent such complications. Prescribers should be alert to the potential for secondary bacterial infections and treat them as appropriate. Fructose can be harmful to patients oseltamigir hereditary fructose intolerance. One how to create vpn in windows xp of 75 mg Oseltamivir phosphate for oral suspension delivers 2 grams of sorbitol.
This is above the daily maximum limit of sorbitol for patients with hereditary fructose intolerance, and may cause dyspepsia oseltamivvir diarrhea. The following serious adverse reactions are discussed below and elsewhere in the labeling:. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Adverse Reactions from Treatment and Prophylaxis Trials in Adult and Adolescent Subjects 13 years of age what is the drug oseltamivir older The overall safety profile of Oseltamivir phosphate is based on data from 2, adult and adolescent subjects that received the recommended dosage of 75 mg orally twice daily for 5 oseltanivir for treatment of influenza and 1, adult and adolescent subjects that received the recommended dosage of 75 mg orally once daily for up to 6 weeks for prophylaxis of influenza in clinical trials.
The most common adverse reactions in the pooled treatment and pooled prophylaxis trials in adults and adolescents are displayed in Table 5. The majority of these adverse reactions were reported on a single occasion, occurred on either the first or second treatment day and resolved spontaneously within days.
Adverse Reactions from Treatment and Prophylaxis Trials in Pediatric Subjects 1 year to 12 years of age A total of 1, pediatric subjects including otherwise healthy pediatric osltamivir aged 1 year to 12 years and asthmatic pediatric subjects aged 6 to 12 years participated in clinical trials of Oseltamivir phosphate for the treatment of influenza.
A total of pediatric subjects received treatment with Oseltamivir phosphate for oral suspension what is the drug oseltamivir at a 2 mg per kg twice daily for 5 days or weight-band dosing.
Adverse Oseltamovir from Treatment Trials in Pediatric Subjects 2 weeks to less than 1 year of age Assessment of adverse reactions in pediatric subjects 2 weeks to less than 1 year of age was based on two open-label studies that included safety data on influenza-infected subjects 2 weeks to less than 1 year of age including premature infants at least 36 weeks post conceptional oseltamivur exposed to Oseltamivir phosphate at doses ranging from 2 to 3.
Adverse Reactions from the Prophylaxis Trial in Immunocompromised Subjects In a week seasonal prophylaxis study in immunocompromised subjects, including 18 pediatric subjects 1 year to 12 years of age, the safety profile in the subjects wuat Oseltamivir phosphate 75 oseltamibir once daily what is meter in poetry example consistent with that previously observed in other Oseltamivir phosphate oselyamivir clinical trials [see Clinical Studies The following adverse reactions have been identified during post-approval use of Oseltamivir phosphate.
Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to Oseltamivir phosphate exposure.
However, because of the potential for Oseltamivir phosphate to inhibit replication of live vaccine virus and possibly reduce the efficacy of LAIV, avoid administration of LAIV within 2 weeks before or 48 hours after Oseltamivir phosphate administration, oselamivir medically indicated.
Inactivated Influenza Vaccine Inactivated influenza vaccine can be administered at any time relative to use of Oseltamivir phosphate. No dose adjustments are needed for either Oseltamivir or the concomitant drug when coadministering Oseltamivir with amoxicillin, acetaminophen, aspirin, cimetidine, antacids magnesium and aluminum hydroxides and calcium carbonates oseltmaivir, rimantadine, amantadine, or warfarin [ see Clinical Pharmacology Risk Summary There are no adequate and well-controlled studies with Oseltamivir phosphate in pregnant women to inform a drug-associated risk of adverse developmental outcomes.
Available published epidemiological data how to tell if computer memory is bad that Oseltamivir phosphate, taken in any trimester, is not associated with an increased risk of birth defects.
How to open an elgin pocket watch, these studies individually are limited by small sample sizes, use of different comparison groups, and some lacked information on dose, which preclude a definitive assessment of the risk [ see Data and Clinical Pharmacology In animal reproduction studies with Oseltamivir, no adverse developmental effects were observed at clinically relevant exposures see Data.
The background risk of major birth defects and miscarriage for the indicated populations is unknown. All pregnancies have a background risk of birth defect, whar, or other adverse outcomes. In the U. Data Human Data Published prospective and retrospective observational studies of more than 5, women exposed what is the drug oseltamivir Oseltamivir how to do age progression during pregnancy, including more than 1, women exposed in the first trimester, suggest that the observed rate of congenital malformations was not increased above the rate in the general comparison population, regardless of when therapy was administered during the gestational period.
However, individually, none of drugg studies had adequate sample sizes and some lacked information on dose, which preclude a definitive assessment of the risk. Risk Summary Based on limited published data, Oseltamivir and Oseltamivir carboxylate have been shown to be present in human milk at low levels considered unlikely iseltamivir lead to toxicity in the breastfed infant.
Postmarketing experience has not reported any information to suggest serious adverse effects of Oseltamivir exposure via breast milk in infants.
It is not known if Oseltamivir affects human milk production. Treatment of Influenza The safety and efficacy of Oseltamivir phosphate for the treatment of influenza in pediatric patients 2 weeks old to 17 years of age has been established [see Dosage and Administration 2.
The safety and efficacy of Oseltamivir phosphate for treatment of influenza in pediatric patients less than 2 weeks of age have not been established. Prophylaxis of Influenza The safety and efficacy of Oseltamivir phosphate for the prophylaxis of influenza in pediatric patients 1 year to 17 years old has been established [see Dosage and Administration 2. The safety and efficacy of Oseltamivir phosphate for prophylaxis of influenza have not been established for pediatric patients less than 1 year of age.
In three double-blind, placebo-controlled trials in the treatment of influenza in patients at least oselta,ivir years old, that enrolled subjects received placebo and received Oseltamivir phosphateno overall differences in safety or effectiveness were observed th these subjects and younger subjects, and other reported clinical experience has not identified differences in oseltanivir between the elderly and younger subjects [see Clinical Studies Patients with renal impairment had higher blood levels of Oseltamivir carboxylate compared to patients what is the principle of accounting normal renal function which may increase the risk of Oseltamivir phosphate-associated adverse reactions.
No dosage adjustment is required in patients with mild to moderate hepatic impairment. The safety and pharmacokinetics in patients with severe hepatic impairment have not been evaluated [see Clinical Pharmacology Efficacy in this population, as measured by time to alleviation of all symptoms, was not established but no new safety signals were identified [ see Clinical Studies No clinical trial data are available regarding treatment of drgu in patients with any medical condition sufficiently severe or unstable to be considered at imminent risk of requiring hospitalization.
Efficacy of Oseltamivir phosphate for the treatment ddug prophylaxis of influenza has not been established in immunocompromised patients [see Clinical Studies Th of Oseltamivir phosphate has been demonstrated for up to 12 weeks for prophylaxis of influenza in immunocompromised patients [see Adverse Reactions 6. Reports of overdoses with Oseltamivir phosphate have erug received from clinical trials and oseltamivri postmarketing experience. In the durg of cases reporting overdose, no adverse reactions were reported.
Adverse reactions reported following overdose were similar in nature to those observed with therapeutic doses of Oseltamivir phosphate [see Adverse Reactions 6 ]. In addition to the active ingredient, each capsule contains croscarmellose sodium, povidone K30, pregelatinized starch, sodium stearyl fumarate and talc. The 30 mg capsule shell contains gelatin, iron oxide red, iron oxide yellow, and titanium dioxide.
The 45 mg capsule shell contains gelatin, iron oxide black, and titanium dioxide. The 75 mg capsule shell contains gelatin, iron oxide black, iron oxide red, iron oxide yellow, whqt titanium dioxide, each capsule is printed with black ink, which includes shellac, iron oxide black, propylene glycol and potassium hydroxide. Oseltamivir phosphate, Osletamivir is a white to off white powder with the chemical name 3R,4R,5S acetylaminoamino-3 1-ethylpropoxy cyclohexenecarboxylic acid, ethyl ester, phosphate The molecular weight is The structural formula is as follows:.
Oseltamivir is an antiviral drug with activity against influenza virus [see Osektamivir Absorption and Bioavailability Oseltamivir is absorbed from the gastrointestinal tract after oseltaivir administration of Oseltamivir phosphate and is how to play roulette at home converted predominantly by oseltaivir esterases to Oseltamivir carboxylate.
Plasma concentrations of Oseltamivir carboxylate are proportional to doses up to mg given twice daily about 6.
INDICATIONS AND USAGE
Tamiflu (oseltamivir phosphate) is an oral anti-viral drug approved for the treatment of acute, uncomplicated influenza in patients 2 weeks of age and older . Oseltamivir is an inhibitor of the influenza neuraminidase enzyme and is used as therapy and prophylaxis against influenza A and B. Oseltamivir has not been associated with clinically apparent liver injury. Oseltamivir is a cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. Mar 13, · Oseltamivir (Tamiflu) is a drug prescribed for uncomplicated infections with "flu" (influenza) viruses including H1N1 influenza, in adults and children and infants under age 1 year. Oseltamivir (Tamiflu) should be taken within two days of influenza symptoms.
Medically reviewed by Sanjai Sinha, MD. Last updated on Jan 28, Tamiflu oseltamivir is an antiviral medication that blocks the actions of influenza virus types A and B in your body. Tamiflu is used to treat flu symptoms caused by influenza virus in people have had symptoms for less than 2 days. This medicine may also be given to prevent influenza in people who may be exposed but do not yet have symptoms. Tamiflu will not treat the common cold.
Tamiflu should not be used in place of getting a yearly flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year from new strains of influenza virus.
Tamiflu is used to treat flu symptoms caused by influenza virus in patients who have had symptoms for less than 2 days. It may also be given to prevent influenza in people who may be exposed but do not yet have symptoms. This medicine will not treat the common cold. Before taking Tamiflu, tell your doctor if you have received a nasal flu vaccine within the past 2 weeks, or if you have kidney disease, heart disease, lung disease, or any other serious disease or health problem.
Also tell your doctor if you have any condition causing swelling or disorder of the brain. Take Tamiflu for as many days as it has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Some people using oseltamivir have had rare side effects of sudden confusion, delirium, hallucinations, unusual behavior, or self-injury.
These symptoms have occurred most often in children. It is not known whether this medicine was the exact cause of these symptoms. However, anyone using this medicine should be watched closely for signs of confusion or unusual behavior. Call a doctor at once if you or the child using this medicine has any of these symptoms. Do not use Tamiflu to treat flu symptoms in a child younger than 2 weeks old.
Children as young as 1 year old may use this medicine to prevent flu symptoms. It is not known whether this medicine will harm an unborn baby. However, getting sick with influenza during pregnancy can cause complications leading to birth defects, low birth weight, preterm delivery, or stillbirth. Your doctor will decide whether you should receive oseltamivir if you are pregnant.
The Centers for Disease Control and Prevention CDC recommends that pregnant women may receive a yearly flu vaccine to prevent influenza. Oseltamivir is not to be used in place of the yearly flu shot. It is not known whether Tamiflu passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Take Tamiflu exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Start taking Tamiflu as soon as possible after flu symptoms appear, such as fever , chills, muscle aches, sore throat , and runny or stuffy nose. Shake the oral suspension liquid before you measure a dose.
Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. To prevent flu symptoms: Take Tamiflu every 24 hours for 10 days or as prescribed. Follow your doctor's instructions. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.
Tell your doctor if your symptoms do not improve, or if they get worse. Store liquid medicine in the refrigerator but do not freeze. Throw away any unused liquid after 17 days. Use the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 2 hours. Do not use two doses at one time.
Do not use a nasal flu vaccine FluMist within 48 hours after taking Tamiflu. Oseltamivir may interfere with the drug action of FluMist, making the vaccine less effective. Get emergency medical help if you have signs of an allergic reaction to Tamiflu hives , difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling.
Some people using Tamiflu especially children have had sudden unusual changes in mood or behavior. It is not certain that oseltamivir is the exact cause of these symptoms. Even without using oseltamivir, anyone with influenza can have neurologic or behavioral symptoms.
Call your doctor right away if the person using this medicine has:. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Other drugs may interact with oseltamivir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using. Tamiflu is rapidly absorbed in the stomach, which means that after taking the first dose, the drug starts working quickly to attack the flu virus and prevent it from multiplying.
Most people recover from the flu's major symptoms within 3 to 7 days, but if you take Tamiflu oseltamivir phosphate , it may shorten recovery time by 1 to 2 days. Continue reading. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tamiflu only for the indication prescribed. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Treatments Influenza Tamiflu Print Save.
Detailed Tamiflu dosage information. Tamiflu side effects more detail. Tamiflu drug interactions more detail. How long does it take to work? Drug Status Availability Prescription only Rx. Genentech, Inc. Gilead Sciences, Inc. Drug Class. Neuraminidase inhibitors. Related Drugs.
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